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KMID : 0604520230490020169
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Journal of the Society of Cosmetic Scientists of Korea
2023 Volume.49 No. 2 p.169 ~ p.176
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Effect of Skin Elasticity Improvement and Anti-oxidant Activity of Stem Cells Extract Derived from Cambium of Aloe
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Kim Dong-Myong
Kim Won-Jin
Lee Hyung-Kon
Kwon Yong-Seong
Choi Yeon-Mea
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Abstract
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In this study, stem cells were extracted from the callus derived from the aloe cambium, and the antioxidant activity and effect of skin elasticity improvement were assessed. The aloe cambium-derived stem cell extract, AloStem and callus showed the survival rate of each 98.27% and 71.31%. In the results of the DPPH antioxidant activity of AloStem and aloe extract, it was confirmed that the antioxidant effect of AloStem was more than twice that of Aloe extract. AloStem did not affect the cytotoxicity of normal human dermal fibroblasts (NHDF) cells up to 0.25% concentration. Also, AloStem increased elastin, COL1A1 and HAS2 mRNA expression levels dose-dependently. Furthermore, to examine lifting effect of skin elasticity using a sheet mask containing AloStem, 21 adult men and women applied the sheet mask in the face, once a day for 2 weeks. As a result, after 2 weeks the skin length was 116.75 ± 5.58 mm before the use of the sheet mask, but after 2 weeks of use, it was confirmed that 0.59% increased to 117.44 ± 5.17 mm. Thus, we concluded that the sheet mask containing AloStem can help the lifting effect of skin elasticity.
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KEYWORD
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aloe, cambium, stem cell, antioxidant activity, skin elasticity
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